The burden of postoperative pulmonary complications (PPCs)

Every year, more than 230 million major surgical procedures requiring general or regional anaesthesia are undertaken worldwide^[1].

	Did you know?
	10% of patients who undergo general anaesthesia and mechanical ventilation will develop postoperative pulmonary complications (PPCs)[1].
	For cardiac and thoracic surgeries or obese patients, the incidence of postoperative pulmonary complications (PPCs) may be higher than 30%[2].

During the intraoperative stage, while initiating anaesthesia, the patient's respiratory system will significantly change. Initially, patients will lose consciousness and the central respiratory drive will be depressed. Then, the use of neuromuscular blocking drugs will paralyze the respiratory muscles, which can lead to a significant decrease of Functional Residual Capacity (FRC) of 15-20%^[3]. Decrease of FRC frequently causes atelectasis and is one of the most common respiratory changes contributing to PPCs during general anaesthesia.

Atelectasis may develop in nearly 90% of patients under general anaesthesia and can persist throughout the postoperative period and even up to several days after surgery^[4].

To prevent atelectasis, at times a higher tidal volume is used to recruit collapsed alveoli, however, this may lead to overdistension or even volutrauma^[5,6]. Furthermore, injury of shearing forces from the repetitive opening and collapse of the alveoli, called "atelectrauma", can induce or worsen existing lung injuries.

High-risk of atelectasis under general anesthesia

Laparoscopic Surgery

One-lung Ventilation

Cardiac Surgery

Obese Patients

Lung protective ventilation is widely recognized as an effective strategy to keep the alveoli open while avoiding barotrauma.

Commonly used strategies include low-tidal volume, optimal PEEP titration, and lung recruitment maneuvers^[7,8].

Protective Ventilation Strategies applied to anaesthesia system

Lower tidal volume

The IMPROVED clinical trial suggested that protective lung ventilation and non-protective ventilation have different tidal volume settings of 6-8ml/kg versus 10-12 ml/kg. In retrospect, the lung protective ventilation group has a lower risk of PPCs with lower levels of ventilation support required and shorter hospital stays after surgery^[9].

However, in a recent randomized clinical trial among adults undergoing major surgery, low tidal volume strategy did not significantly reduce PPCs within the first 7 days after surgery if the PEEP setting is fixed to 5 cmH₂O, suggesting clinical outcomes may not improve with only low tidal volume strategy^[10].

Optimal PEEP for individualized patient care

A study on patients with a high risk of atelectasis, such as those who have undergone laparoscopic abdominal surgery, shows that individualized PEEP setting could reduce postoperative atelectasis while improving intraoperative oxygenation with minimum side effects^[11,12]. The same result can be seen in obese patients, who require higher PEEP to keep the lungs open due to higher abdominal pressure^[13].

Therefore, optimal PEEP titration during anaesthesia is recommended to improve lung function during and after surgery. The optimal PEEP is defined as the PEEP setting that leads to the lowest intrapulmonary shunt without compromising cardiac output^[14]. But how is optimal PEEP titration for individual patients done?

There are several PEEP titration methods commonly used by clinicians, including: pulmonary compliance directed methods, best oxygenation, Vds/Vt guided technique based on imaging, and transpulmonary pressure directed procedures^[11,12,15].

Recruitment maneuvers

Recruitment maneuver is a strategy aimed at re-expanding collapsed alveoli and augmenting the exchange surface at the alveoli-capillary membrane, to avoid intra-and postoperative lung complications^[16].

So how is lung recruitment commonly done in the operating room? A wide variety of recruitment maneuvers have been reported and used in practice, including sustained inflation, stepwise increase of tidal volume ventilation, incremental PEEP procedure, etc. The best recruitment maneuver technique may vary according to the specific patients and circumstances^[7,17].

Lung protective ventilation strategy

Low tidal volume

Optimal PEEP titration

Recruitment maneuvers

What Mindray can offer

1 Vt/IBW indicator
Vt/IBW can be calculated as the tidal volume changes, offering clinicians clear indication of appropriate tidal volume settings.

2 Transpulmonary pressure monitoring
Independent monitoring for esophageal pressure, to support customized ventilation settings for individual patients.

3 Recruitment Pro Tool

Two optional maneuvers: stepwise PEEP or sustained inflation.

Multiple criteria to evaluate recruitment effectiveness.

A scheduled recruitment can be performed automatically

Striving for best practices towards patient safety in anaesthesia settings, Mindray incorporates various protective ventilation tools in the A8/A9 anaesthesia systems, which contributes to safer patient management by reducing the risk of PPCs and improving patient outcomes.